Coenzyme Q10 (CoQ10) plays its primary role in cellular energy metabolism: in the mitochondrion; through the Krebs cycle, glucose and oxygen are transformed into cellular energy (ATP). CoQ10 decreases with aging, with malnutrition, with some drugs (statins), and after intense muscular effort; in these cases the only useful source of CoQ10 is dietary supplementation. Statins used to lower cholesterol significantly reduce the biosynthesis of CoQ10. Chronic CoQ10 deficiency can cause muscle weakness and heart failure.

Nutritionism – In dietary programs for subjects with high fat mass, the appropriate presence of CoQ10 promotes cellular metabolism, reduces the sense of fatigue, promotes the activation of lipolysis, with consequent reduction of fat mass (weight reduction), enhances cellular bioenergetics (boosting lean body mass), energizing the heart and muscles.

CoQ10 is essential for the heart; very useful, in cardiopathic and/or elderly subjects, in the prevention and treatment of various forms of cardiovascular diseases. Several studies show that patients with congestive heart failure and other heart diseases have low levels of CoQ10 in myocardial tissue and that daily dietary supplementation, in addition to “usual care”, has been shown to improve their condition.

In a study published in the Archives of Neurology, researchers found, in Neuropathic subjects, that CoQ10 associated with Vit. E slows down the deterioration of Parkinson’s disease by 44%. The greatest benefits were seen in daily activities: eating, washing, dressing and walking. It also seems very helpful in preventing migraines. Integration with CoQ10 is essential in all neurological pathologies, based on mitochondrial deficiency.
CoQ10 may improve the tolerability of chemotherapy; it can protect healthy tissues from the oxidative stress generated by chemo and radiotherapy. Due to its role in the mitochondrion, it favors the production of ATP, cellular energy; therefore it can protect the heart from acute and chronic damage, and reduce the sense of tiredness (Fatigue).

In athletes who take CoQ10-based supplements, much evidence demonstrates a significant improvement in the bioenergetics of the heart muscle and skeletal muscles, with an evident benefit in muscle strength under effort. The activity of CoQ10 at the level of skeletal muscles, expressed as the ability to improve energy production, has led to its use in sports medicine, where some studies carried out on professional athletes have demonstrated the positive effect on physical performance indices and of muscle tone: rapid recovery, absence of lactic acidosis, reduced sense of fatigue.
Several studies have shown that coenzyme Q10, contained in various foods and food supplements, increases the protection of sperm from oxidative stress. Several studies have shown that patients with infertility and semenological picture of asthenozoospermia (low sperm motility), aged between 25 and 42 years, after three to six months treatment with CoQ10 (at least 200 mg per day) have observed a increased concentration and motility of sperm.
During pregnancy, the increase in maternal, placental and fetal tissues induces a state of oxidative stress, which must be kept under control to allow the growth and ideal maturation of the fetus and newborn. The condition of absolute oxidative stress can favor spontaneous and frequent abortion.

Vitamin B1, or thiamin, is part of the so-called water-soluble vitamins, those which cannot be accumulated in the body, but must be regularly ingested through food.
Vitamin B1 contributes to the important process of converting glucose into energy.
Vitamin B1 deficiency causes damage to the nervous and cardiovascular systems and a general state of wastingness and weight loss resulting from an increasing difficulty in swallowing food accompanied by heavy salivation and vomiting.
Vitamin B1 deficiency can also cause cardiac alterations, neurological disorders, pupil dilation and spinal hypersensitivity.

There are no problems due to an excess intake of vitamin B1, or thiamin, because the excess doses are eliminated from our body, quickly after intake, via the urine.